Document Detail


The tumorigenicity of human embryonic and induced pluripotent stem cells.
MedLine Citation:
PMID:  21390058     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The unique abilities of human pluripotent stem cells to self-renew and to differentiate into cells of the three germ layers make them an invaluable tool for the future of regenerative medicine. However, the same properties also make them tumorigenic, and therefore hinder their clinical application. Hence, the tumorigenicity of human embryonic stem cells (HESCs) has been extensively studied. Until recently, it was assumed that human induced pluripotent stem cells (HiPSCs) would behave like their embryonic counterparts in respect to their tumorigenicity. However, a rapidly accumulating body of evidence suggests that there are important genetic and epigenetic differences between these two cell types, which seem to influence their tumorigenicity.
Authors:
Uri Ben-David; Nissim Benvenisty
Related Documents :
8276448 - Status of different immune cells during regression of a rat histiocytoma.
1374678 - Circulating prostate specific antigen-positive cells correlate with metastatic prostate...
9516828 - Expression of a 260 kda neuroblastoma surface antigen, the target of cytotoxic natural ...
15457088 - Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of c...
15102478 - Age- and irradiation-associated loss of bone marrow hematopoietic function in mice is r...
7202578 - A comparative study of the shedding process mouse erythrocyte binding receptors on peri...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-10
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  -     ISSN:  1474-1768     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pulse pressure and systolic night-day ratio interact in prediction of macrovascular disease in patie...
Next Document:  CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?