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The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword.
MedLine Citation:
PMID:  21293052     Owner:  NLM     Status:  In-Data-Review    
Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.
Michael Hölzel; Kaspar Burger; Bastian Mühl; Mathias Orban; Markus Kellner; Dirk Eick
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncotarget     Volume:  1     ISSN:  1949-2553     ISO Abbreviation:  Oncotarget     Publication Date:  2010 May 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101532965     Medline TA:  Oncotarget     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
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