| The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword. | |
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MedLine Citation:
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PMID: 21293052 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected. |
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Authors:
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Michael Hölzel; Kaspar Burger; Bastian Mühl; Mathias Orban; Markus Kellner; Dirk Eick |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oncotarget Volume: 1 ISSN: 1949-2553 ISO Abbreviation: Oncotarget Publication Date: 2010 May |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101532965 Medline TA: Oncotarget Country: United States |
Other Details:
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Languages: eng Pagination: 43-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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