| The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice. | |
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MedLine Citation:
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PMID: 22711758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Cardiovascular disease is the most common cause of death in the world and atherosclerosis, an inflammatory process in the vessel wall, accounts for the majority of these deaths. The tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) has been shown to inhibit inflammation in different experimental autoimmune disease models. However, the effect of 3-HAA in atherosclerosis has never been explored. METHODS AND RESULTS: In this study, we used the atherosclerosis prone Ldlr-/- mice, and cell culture experiments to evaluate the role of 3-HAA in atherosclerosis. Eight weeks treatment with 3-HAA significantly reduced the lesion size in the aorta, and modulated local and systemic inflammatory responses. 3-hydroxyanthranilic acid inhibited the uptake of oxLDL by macrophages, an initiating event in the formation of foam cells, a major cellular component of atherosclerotic lesions. Surprisingly, 3-HAA significantly affected plasma cholesterol and triglyceride levels in Ldlr-/- mice, likely due to modulation of signalling through peroxisome proliferator-activated receptors. CONCLUSION: 3-Hydroxyanthranilic acid inhibits atherosclerosis by regulating lipid metabolism and inflammation, two major components of this disease. |
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Authors:
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Lei Zhang; Olga Ovchinnikova; Andreas Jönsson; Anna M Lundberg; Martin Berg; Göran K Hansson; Daniel F J Ketelhuth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-06-18 |
Journal Detail:
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Title: European heart journal Volume: 33 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-15 Completed Date: 2012-12-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 2025-34 Citation Subset: IM |
Affiliation:
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Department of Medicine, Center for Molecular Medicine, L8:03, Karolinska University Hospital, Karolinska Institute, Stockholm SE-17176, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxyanthranilic Acid
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pharmacology* Animals Atherosclerosis / immunology, prevention & control* Diet, High-Fat Free Radical Scavengers / pharmacology* Hypercholesterolemia / immunology, prevention & control* Hypolipidemic Agents / pharmacology Immunity, Cellular / drug effects Immunohistochemistry Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism Lipoproteins, LDL / drug effects, metabolism Macrophages / drug effects, metabolism Mice Mice, Inbred Strains RNA, Messenger / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Hypolipidemic Agents; 0/Indoleamine-Pyrrole 2,3,-Dioxygenase; 0/Lipoproteins, LDL; 0/RNA, Messenger; 0/oxidized low density lipoprotein; 548-93-6/3-Hydroxyanthranilic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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