| The trypanocidal action of homidium, quinapyramine and suramin. | |
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MedLine Citation:
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PMID: 13712404 Owner: NLM Status: OLDMEDLINE |
Abstract/OtherAbstract:
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Homidium, quinapyramine, and suramin (Group II compounds) produce their trypanocidal effect in vivo only after a latent period of 24 hr. or more, during which time the trypanosomes may continue to multiply; this is in contrast to trivalent arsenical and diamidine compounds (Group I compounds), which begin to act immediately. Group II compounds also differ from Group I compounds in that (a) they have only a slight tendency to combine with trypanosomes, (b) they have little trypanocidal action in vitro, but (c) they make trypanosomes non-infective to fresh subinoculated mice. To explain these features it is postulated that homidium, quinapyramine, and suramin first combine in small amounts with some receptor on the trypanosome and then block some biochemical system which produces a hypothetical substance X which is needed for cell division of the trypanosome; the trypanosome is supposed to contain a preformed store of this substance X sufficient for several divisions to take place; and it is only when this store is exhausted that cell division is prevented and the trypanosome eventually dies. |
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Authors:
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F HAWKING; A B SEN |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology and chemotherapy Volume: 15 ISSN: 0366-0826 ISO Abbreviation: Br J Pharmacol Chemother Publication Date: 1960 Dec |
Date Detail:
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Created Date: 1961-12-01 Completed Date: 1998-11-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0154627 Medline TA: Br J Pharmacol Chemother Country: Not Available |
Other Details:
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Languages: eng Pagination: 567-70 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Quinolines
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pharmacology* Suramin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Quinolines; 145-63-1/Suramin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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