Document Detail


The trunk neural crest and its early glial derivatives: a study of survival responses, developmental schedules and autocrine mechanisms.
MedLine Citation:
PMID:  14962738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regulation of survival during gliogenesis from the trunk neural crest is poorly understood. Using adapted survival assays, we directly compared crest cells and the crest-derived precursor populations that generate satellite cells and Schwann cells. A range of factors that supports Schwann cells and glial precursors does not rescue crest, with the major exception of neuregulin-1 that rescues crest cells provided they contact the extracellular matrix. Autocrine survival appears earlier in developing satellite cells than Schwann cells. Satellite cells also show early expression of S100beta, BFABP and fibronectin and early survival responses to IGF-1, NT-3 and PDGF-BB that in developing Schwann cells are not seen until the precursor/Schwann cell transition. These experiments define novel differences between crest cells and early glia and show that entry to the glial lineage is an important point for regulation of survival responses. They show that survival mechanisms among PNS glia differ early in development and that satellite cell development runs ahead of schedule compared to Schwann cells in several significant features.
Authors:
Ashwin Woodhoo; Charlotte H Dean; Anna Droggiti; Rhona Mirsky; Kristjan R Jessen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  25     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-13     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-41     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autocrine Communication / physiology*
Cell Differentiation / physiology*
Cell Line, Tumor
Cell Lineage / physiology
Cell Survival / physiology
Cells, Cultured
Fetus
Fibronectins / metabolism
Nerve Growth Factors / metabolism,  pharmacology
Neural Crest / cytology,  embryology*,  metabolism
Neuregulin-1 / metabolism,  pharmacology
Neuroglia / cytology,  metabolism*
Organ Culture Techniques
Peripheral Nervous System / cytology,  embryology*,  metabolism
Rats
Rats, Sprague-Dawley
S100 Proteins / metabolism
Satellite Cells, Perineuronal / cytology,  metabolism
Schwann Cells / cytology,  metabolism
Stem Cells / cytology,  metabolism*
Chemical
Reg. No./Substance:
0/Fibronectins; 0/Nerve Growth Factors; 0/Neuregulin-1; 0/S100 Proteins; 0/S100A1 protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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