| The trunk neural crest and its early glial derivatives: a study of survival responses, developmental schedules and autocrine mechanisms. | |
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MedLine Citation:
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PMID: 14962738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulation of survival during gliogenesis from the trunk neural crest is poorly understood. Using adapted survival assays, we directly compared crest cells and the crest-derived precursor populations that generate satellite cells and Schwann cells. A range of factors that supports Schwann cells and glial precursors does not rescue crest, with the major exception of neuregulin-1 that rescues crest cells provided they contact the extracellular matrix. Autocrine survival appears earlier in developing satellite cells than Schwann cells. Satellite cells also show early expression of S100beta, BFABP and fibronectin and early survival responses to IGF-1, NT-3 and PDGF-BB that in developing Schwann cells are not seen until the precursor/Schwann cell transition. These experiments define novel differences between crest cells and early glia and show that entry to the glial lineage is an important point for regulation of survival responses. They show that survival mechanisms among PNS glia differ early in development and that satellite cell development runs ahead of schedule compared to Schwann cells in several significant features. |
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Authors:
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Ashwin Woodhoo; Charlotte H Dean; Anna Droggiti; Rhona Mirsky; Kristjan R Jessen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 25 ISSN: 1044-7431 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-02-13 Completed Date: 2004-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 30-41 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autocrine Communication / physiology* Cell Differentiation / physiology* Cell Line, Tumor Cell Lineage / physiology Cell Survival / physiology Cells, Cultured Fetus Fibronectins / metabolism Nerve Growth Factors / metabolism, pharmacology Neural Crest / cytology, embryology*, metabolism Neuregulin-1 / metabolism, pharmacology Neuroglia / cytology, metabolism* Organ Culture Techniques Peripheral Nervous System / cytology, embryology*, metabolism Rats Rats, Sprague-Dawley S100 Proteins / metabolism Satellite Cells, Perineuronal / cytology, metabolism Schwann Cells / cytology, metabolism Stem Cells / cytology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 0/Nerve Growth Factors; 0/Neuregulin-1; 0/S100 Proteins; 0/S100A1 protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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