| trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. | |
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MedLine Citation:
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PMID: 8223273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells. Direct comparison with trk and trkB developmental expression patterns permits the following observations. (1) trkC is expressed in novel neural tissues where other Trk genes are silent. (2) Some tissues appear to coexpress trkB and trkC receptors in the embryo and in the adult. (3) trkC expression can be detected in the gastrulating embryo. These data provide insights into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Finally, interspecific mouse backcrosses have been used to map the location of each of the Trk genes on mouse chromosomes. Alignment with available chromosomal maps identify possible linkage between the Trk genes and known neurological mutations. |
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Authors:
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L Tessarollo; P Tsoulfas; D Martin-Zanca; D J Gilbert; N A Jenkins; N G Copeland; L F Parada |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 118 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-12-09 Completed Date: 1993-12-09 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 463-75 Citation Subset: IM |
Affiliation:
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Molecular Embryology Section, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702-1201. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breeding Chromosome Mapping Gastrula / physiology* Gene Expression / physiology* In Situ Hybridization Mice / embryology Nerve Growth Factors / genetics* Nervous System / embryology* Neurotrophin 3 Proto-Oncogene Proteins / analysis*, genetics, physiology Receptor Protein-Tyrosine Kinases / analysis*, genetics, physiology Receptor, trkA Receptors, Nerve Growth Factor / analysis*, genetics*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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N01-CO-74101/CO/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/Neurotrophin 3; 0/Proto-Oncogene Proteins; 0/Receptors, Nerve Growth Factor; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, trkA |
| Comments/Corrections | |
Erratum In:
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Development 1993 Aug;118(4):following 1384 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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