Document Detail

The triplet genetic code had a doublet predecessor.
MedLine Citation:
PMID:  15748913     Owner:  NLM     Status:  MEDLINE    
Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons GNN. Evidence for this scenario is presented based on the properties of aminoacyl-tRNA synthetases, amino acids and nucleotide bases.
Apoorva Patel
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Publication Detail:
Type:  Journal Article     Date:  2004-12-29
Journal Detail:
Title:  Journal of theoretical biology     Volume:  233     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  IM    
Centre for High Energy Physics and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India.
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MeSH Terms
Amino Acid Motifs
Amino Acyl-tRNA Synthetases / genetics
Base Composition
Conserved Sequence
Evolution, Molecular*
Genetic Code
Models, Genetic*
Trinucleotide Repeats*
Reg. No./Substance:
0/Codon; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

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