| A triclosan-containing compomer reduces Lactobacillus spp. predominant in advanced carious lesions. | |
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MedLine Citation:
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PMID: 15876453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the antimicrobial effect of acid etching or a triclosan-containing compomer on the cultivable microflora of incompletely excavated dentinal carious lesions. METHODS: Thirty detinal lesions were opened with a diamond burr. Subsequent to removal of the softened biomass a sample of dentin was taken from the cavity floor with a round bur. Ten cavities each were treated with 36% phosphoric acid (PH) for 15s, covered with a triclosan-containing compomer (TC) or received no treatment as control (CO). All lesions were restored with a compomer composite. Sampling was performed directly after etching in the PH group and at re-entry after 6 weeks in all groups. Aliquots were plated on blood agar and selective media for Lactobacilli (Rogosa) and mutans Streptococci (MSB). Cultures were incubated anaerobically for 7 days at 37 degrees C prior to quantitative assessment and biotyping of the isolates. RESULTS: Application of phosphoric acid resulted in initial reduction of the totally cultivable microflora (p=0.006). Evaluation of the total number of cultivable microflora after 6 weeks revealed no differences between the groups (p>0.05). Lactobacilli counts were significantly lower in the TC group compared to the PH and CO groups (p<0.05). No difference was detected between the PH and CO groups after 6 weeks. SIGNIFICANCE: Phosphoric acid initially reduces the number of microorganisms in carious dentin but not in the longer term. The experimental triclosan composite suppresses Lactobacilli species over a period of 6 weeks. |
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Authors:
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Michael J Wicht; Rainer Haak; Susanne Kneist; Michael J Noack |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Dental materials : official publication of the Academy of Dental Materials Volume: 21 ISSN: 0109-5641 ISO Abbreviation: Dent Mater Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-09 Completed Date: 2006-07-24 Revised Date: 2010-08-26 |
Medline Journal Info:
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Nlm Unique ID: 8508040 Medline TA: Dent Mater Country: England |
Other Details:
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Languages: eng Pagination: 831-6 Citation Subset: D |
Affiliation:
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Center of Dental Medicine, Policlinic of Operative Dentistry and Periodontology, University of Cologne, Kerpener Str. 32, D-50931 Köln, Germany. michael.wicht@medizin.uni-koeln.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid Etching, Dental Actinomyces / drug effects Adult Anti-Infective Agents, Local / administration & dosage, therapeutic use* Colony Count, Microbial Compomers* / chemistry Composite Resins / chemistry Dental Caries / microbiology*, therapy Dental Restoration, Permanent Dentin / microbiology* Female Follow-Up Studies Humans Lactobacillus / drug effects* Male Phosphoric Acids / pharmacology Polymethacrylic Acids / chemistry Streptococcus / drug effects Triclosan / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Compomers; 0/Composite Resins; 0/Dyract; 0/Phosphoric Acids; 0/Polymethacrylic Acids; 0/Prime and Bond NT; 3380-34-5/Triclosan; 7664-38-2/phosphoric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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