| A trial of topical prednisolone acetate before intravitreal triamcinolone acetonide decreases intraocular pressure spikes. | |
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MedLine Citation:
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PMID: 20847754 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To compare adverse intraocular pressure (IOP) spikes in patients receiving intravitreal triamcinolone acetonide (IVTA) in 2 cohorts: (i) patients who underwent a topical prednisolone acetate trial (PAT) without incurring a short-term IOP rise, and (ii) control patients who did not undergo a PAT. DESIGN: Retrospective cohort study. PARTICIPANTS: Charts of all patients who underwent any intravitreal injection during the study period were reviewed (n = 1150). METHODS: Patients in the PAT group received a 6-week course of prednisolone acetate 1% 4 times per day and had an IOP that did not rise above 25 mm Hg or above 8 mm Hg over the IOP in the contralateral eye. Patients undergoing a PAT and having a short-term IOP rise were not studied. Control patients did not receive a PAT. All patients received 12-20 mg of IVTA. Patients were followed for a minimum of 6 weeks and follow-up lasted for 1 year or until intraocular surgery or another IVTA injection was performed. RESULTS: There were 97 patients in the PAT cohort and 75 control patients. Patients in the PAT cohort had a lower proportional rise between maximum IOP and baseline (43%) compared with controls (64%) (p = 0.035). Patients in the PAT group also had a lower risk of incurring a 40% (p = 0.05), 60% (p = 0.018), and 100% (p = 0.045) increase in maximum IOP (vs baseline) compared with controls and were less likely to require glaucoma filtration surgery (p = 0.035). CONCLUSIONS: Patients undergoing a PAT who did not have a subsequent short-term IOP rise had a lower risk of severe IOP spikes after IVTA compared with those patients receiving IVTA but not having undergone a PAT. |
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Authors:
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Hussein Hollands; Gamal Seif; Simon Hollands; Jeffrey Gale |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Volume: 45 ISSN: 0008-4182 ISO Abbreviation: Can. J. Ophthalmol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045312 Medline TA: Can J Ophthalmol Country: Canada |
Other Details:
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Languages: eng Pagination: 484-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Queen's University, Kingston, Ont. hussein.hollands@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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