| A trial of silver-zinc-allantoinate in the treatment of leg ulcers. | |
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MedLine Citation:
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PMID: 871247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three hundred thirty-nine of 400 chronic cutaneous ulcers in 264 patients (including some with multiple or bilateral ulcers of both) were healed with silver-zinc-allantoinate creamed (AZAC 1%). Some of the patients treated had failed to respond to medicated wrappings, saline dressings, and various other therapeutic agents, including antibiotics. In one week of treatment with AZAC 1%, bacterial counts were reduced on the average from approximately 2 X 10(7) to 2 X 10(5) (99%). Silver-zinc-allantoinate cream also demonstrated a wide spectrum of antimicrobial activity. It did not give rise to resistance by the infecting organisms, was nonallergenic, debrided necrotic tissue, and stimulated healthy granulation. Treatment was well tolerated, side effects being limited to a burning sensation in three patients. Most patients cared for themselves at home with minimal interference in their usual daily activities. |
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Authors:
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H W Margraf; T H Covey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 112 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-06-30 Completed Date: 1977-06-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 699-704 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Adult Aged Allantoin / therapeutic use* Animals Burns / drug therapy Child Dose-Response Relationship, Drug Drug Combinations Female Humans Leg Ulcer / drug therapy*, microbiology Male Microbial Sensitivity Tests Middle Aged Rats Recurrence Silver / therapeutic use* Varicose Ulcer / drug therapy Wound Healing / drug effects Wound Infection / drug therapy Zinc / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 7440-22-4/Silver; 7440-66-6/Zinc; 97-59-6/Allantoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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