Document Detail

A trial of silver-zinc-allantoinate in the treatment of leg ulcers.
MedLine Citation:
PMID:  871247     Owner:  NLM     Status:  MEDLINE    
Three hundred thirty-nine of 400 chronic cutaneous ulcers in 264 patients (including some with multiple or bilateral ulcers of both) were healed with silver-zinc-allantoinate creamed (AZAC 1%). Some of the patients treated had failed to respond to medicated wrappings, saline dressings, and various other therapeutic agents, including antibiotics. In one week of treatment with AZAC 1%, bacterial counts were reduced on the average from approximately 2 X 10(7) to 2 X 10(5) (99%). Silver-zinc-allantoinate cream also demonstrated a wide spectrum of antimicrobial activity. It did not give rise to resistance by the infecting organisms, was nonallergenic, debrided necrotic tissue, and stimulated healthy granulation. Treatment was well tolerated, side effects being limited to a burning sensation in three patients. Most patients cared for themselves at home with minimal interference in their usual daily activities.
H W Margraf; T H Covey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  112     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-704     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Topical
Allantoin / therapeutic use*
Burns / drug therapy
Dose-Response Relationship, Drug
Drug Combinations
Leg Ulcer / drug therapy*,  microbiology
Microbial Sensitivity Tests
Middle Aged
Silver / therapeutic use*
Varicose Ulcer / drug therapy
Wound Healing / drug effects
Wound Infection / drug therapy
Zinc / therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 7440-22-4/Silver; 7440-66-6/Zinc; 97-59-6/Allantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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