| A trial procedure to prevent aneurysm formation of the coronary arteries by steroid pulse therapy in Kawasaki disease. | |
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MedLine Citation:
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PMID: 7131714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixty patients with Kawasaki disease in the acute phase were studied using a two-dimensional echocardiography. Coronary lesions in Kawasaki disease were characterized echocardiographically by an increase of echo density of the coronary artery and by dilatation or aneurysm of the coronary artery. These findings appeared in the sequence mentioned above in patients who were studied serially. In the group treated with corticosteroid, 62% of the patients showed a disappearance or an improvement of the coronary dilatation or aneurysm, while only 33% of untreated patients showed such an improvement. In patients with coronary aneurysms on the initial echocardiogram, 53% of the pulse therapy group showed an improvement, but none of the untreated group did. A similar result was obtained by an analysis of its therapeutical effect, according to the number of vessels involved. Thus, corticosteroid pulse therapy was shown to be effective for the prevention of coronary arterial aneurysms in Kawasaki disease, if it was given in a sufficient dose in the acute phase of this disease. |
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Authors:
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Y Kijima; T Kamiya; A Suzuki; O Hirose; H Manabe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 46 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1239-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Aneurysm / prevention & control* Child, Preschool Coronary Disease / prevention & control* Echocardiography Humans Lymphatic Diseases / drug therapy* Mucocutaneous Lymph Node Syndrome / complications, drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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