Document Detail

The trend in newly diagnosed Crohn's disease and extraintestinal manifestations of Crohn's disease in central China: a retrospective study of a single center.
MedLine Citation:
PMID:  22895389     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS: The incidence of Crohn's disease (CD) is increasing and has already become a refractory disorder in China. Data on extraintestinal manifestations (EIMs) in CD are rare, especially in Asians. We aimed to evaluate the trend of newly diagnosed CD and the prevalence and risk factors of EIMs in a clinical center in central China. MATERIALS AND METHODS: A total of 153 patients with CD were selected from the center from 1986 to 2011. Demographic and clinical data were collected from the center. The prevalence and risk factors of EIMs were retrospectively analyzed. RESULTS: The cases of CD increased from one in 1986 to 24 in 2011. It seemed to have two peaks for age at diagnosis: 21-25 and 36-40 years. Among these patients, 20 (13.07%) had one to three EIMs. The following EIMs were diagnosed: arthritis (4.58%), pyoderma gangrenosum (0.65%), erythema nodosum (1.31%), aphthous stomatitis (7.84%), ankylosing spondylitis (0.65%), and psoriasis (0.65%). In univariate analysis, patients with EIMs seemed to have shorter disease duration at diagnosis (P<0.001); those treated with intravenous injection of corticosteroids, immunosuppressants, and infliximab before or recently were the most susceptible to EIMs (P=0.012, 0.005, and 0.026, respectively). Multivariate analysis was performed by logistic regression to identify the risk factors of EIMs subsequently; however, no risk factors were identified (P>0.005). CONCLUSION: The incidence of CD was increasing remarkably at our center, and the age distributions were concentrated in the 21-25- and 36-40-year age groups. EIMs seemed to be rare in our Chinese patients with CD, and no risk factors correlated with EIMs, which was quite different from Western countries.
Fengming Yi; Min Chen; Meifang Huang; Jin Li; Junzhang Zhao; Lixia Li; Bing Xia
Related Documents :
22795729 - Risk factors associated with secondary sarcomas in childhood cancer survivors: a report...
20230729 - Influence of heavy episodic drinking on the relation between men's locus of control and...
21574819 - Apparent bioavailability of isoflavones in urinary excretions of postmenopausal malay w...
3604749 - Alcohol consumption and sudden coronary death in middle-aged finnish men.
22320939 - Epidemiologic risk factors for esophageal cancer development.
23172319 - Incidence and epidemiologic associations of corneal infiltrates with silicone hydrogel ...
1526259 - Early pregnancy factor (epf) as a marker for the diagnosis of subclinical embryonic loss.
23453359 - Epidemiology and risk factors for oesophageal adenocarcinoma.
9262279 - Chlamydial serology in 1303 asymptomatic subfertile couples.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  -     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine bThe Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Leptin-mediated reactive oxygen species production does not significantly affect primary mouse hepat...
Next Document:  Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update.