Document Detail

The trend of VEGF-A and PlGF in pregnant patients: a perspective case-control study on 214 women.
MedLine Citation:
PMID:  22675957     Owner:  NLM     Status:  In-Process    
OBJECTIVE: The aim of this study was to measure plasmatic concentrations of vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PIGF) in pregnant women, and to evaluate their relationship with age, hormonal status, gestational age, and different diseases of pregnancy.
METHODS: We selected a control group of 163 patients (96 fertile and 67 in menopause) and a group of 214 pregnant patients during the whole gestational period. VEGF-A and PlGF were assayed by ELISA and EIA methods, respectively. Statistical analysis was performed using the Mann-Whitney test.
RESULTS: The control group showed mean VEGF-A and PlGF values of 89.87 pg/ml and 10.22 pg/ml, respectively; PlGF showed the highest values in menopausal patients. The group of pregnant patients showed VEGF-A values of 27.05 pg/ml and PlGF values of 231.36 pg/ml respectively, with lower (for the VEGF-A) and higher (for the PlGF) statistical significance. These values were not influenced by biological age, but were related to gestational age: VEGF-A showed a decrease and PlGF an increase particularly after the 20th gestational week. PlGF showed a statistically significant decrease compared to physiological gestation in spontaneous and threatened abortions (p < 0.0001) and in ectopic pregnancies (p < 0.0001), an increase in ultrasound and CTG alterations (p < 0.05), and threatened premature delivery and uterine hypercontractility (p < 0.01); on the other hand VEGF-A showed a statistically significant increase in ectopic pregnancies (p < 0.05).
CONCLUSIONS: VEGF-A and PlGF may play a diagnostic and prognostic role in pregnancy. Further studies are required to better understand the meaning of variability of their values.
T S Patrelli; S Gizzo; M Plebani; D Basso; G Capobianco; C Bartolucci; A Bacchi Modena; M Rondinelli; G B Nardelli
Related Documents :
22675957 - The trend of vegf-a and plgf in pregnant patients: a perspective case-control study on ...
11381997 - Anaerobic treatment of landfill leachate by sulfate reduction.
619327 - Comparison of fetal maturity evaluation with ultrasonic biparietal diameter and amnioti...
568387 - Lecithin/sphingomyelin ratios centrifuged and uncentrifuged amniotic fluid.
15529297 - Antihypertensive therapy in pregnancy.
16303637 - A rat model of preeclampsia.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  39     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Department of Gynecology and Reproductive Medicine, University of Padua, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Malignant disease as a risk factor for surgical site infection.
Next Document:  Immunohistochemical changes of adenomyosis after heat therapy: comparison of radiofrequency myolysis...