| The treatment of urinary tract infections in out-patients A double-blind comparison between trimethoprim and nitrofurantoin. | |
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MedLine Citation:
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PMID: 7016626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate of side-effects should today be more important for the choice of an agent for treatment of acute urinary tract infections than the cure rate, as this usually is above 90%. The side effects with co-trimoxazole (trimethoprim-sulphamethoxazol) have been viewed as caused mainly by the sulphonamide component. In this randomized, double-blind trial Group A has been treated with trimethoprim 200 mg x 2 and Group B with nitrofurantoin 50 mg x 4 for a duration of 10 days. There was no difference in cure rate between the two groups. The rate of side-effects was 26% in Group A and 12% in Group B. In Group A 12% had skin eruptions, mostly appearing on Day 7 or later, in Group B 1.3% had eruptions. These differences are statistically significant (p less than 0.05). This result, together with a survey of the literature, indicates that the frequency of these rashes might be related both to dosage and duration of treatment. The origin of the side-effects caused by co-trimoxazole should be reconsidered. The in vitro sensitivity against trimethoprim and nitrofurantoin was tested using a disc diffusion method in 98 infecting strains from patients in this study. Two per cent were resistant against trimethoprim and 81% against nitrofurantoin. We found no correlation between the size of the inhibition zone and bacteriological cure rate. This makes the value of the disc diffusion method in out-patients with acute urinary tract infections questionable. |
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Authors:
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J Sander; E Aandahl; H Fellner; S Kalstad |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; In Vitro; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of international medical research Volume: 9 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 1981 |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 181-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bacterial Infections / drug therapy* Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Nitrofurantoin / adverse effects, therapeutic use* Trimethoprim / adverse effects, therapeutic use* Urinary Tract Infections / drug therapy* |
| Chemical | |
Reg. No./Substance:
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67-20-9/Nitrofurantoin; 738-70-5/Trimethoprim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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