Document Detail

The treatment of postperfusion bleeding using epsilon-aminocaproic acid, cryoprecipitate, fresh-frozen plasma, and protamine sulfate.
MedLine Citation:
PMID:  496496     Owner:  NLM     Status:  MEDLINE    
The evaluation of excessive hemorrhage was carried out in 774 patients after cardiopulmonary bypass. Excessive hemorrhage was defined in any adult patient as chest tube drainage of more than 600 ml within the first eight hours after operation. Using the prothrombin time, partial thromboplastin time, fibrinogen level, and tri-F titer tests, it was possible to differentiate medical from surgical bleeding. Hyperfibrinolytic bleeding was the most frequently identifiable coagulation disorder and occurred in 159 patients (20%). All these patients were successfully treated with Amicar (epsilon-aminocaproic acid) alone, or with Amicar supplemented with cryoprecipitate or fresh-frozen plasma. Three patients (0.4%) were noted to have residual heparin and required additional protamine sulfate. Five patients (0.6%) had normal coagulation studies and required immediate reexploration. The overall blood consumption per patient was 2.1 units of packed cells. Whole blood and platelets were not used.
C J Lambert; A J Marengo-Rowe; J E Leveson; R H Green; J P Thiele; G F Geisler; M Adam; B F Mitchel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  28     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-4     Citation Subset:  AIM; IM    
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MeSH Terms
6-Aminocaproic Acid / administration & dosage,  therapeutic use*
Aminocaproic Acids / therapeutic use*
Blood Transfusion*
Cardiopulmonary Bypass* / adverse effects
Hemorrhage / etiology,  therapy*
Postoperative Complications / therapy*
Protamines / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Aminocaproic Acids; 0/Protamines; 60-32-2/6-Aminocaproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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