| The treatment of oropharyngeal candidiasis in HIV-infected patients with oral amphotericin B suspension. | |
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MedLine Citation:
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PMID: 15468434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oropharyngeal candidiasis (OPC) is the most frequent opportunistic infection associated with HIV infection. Therapies such as topical clotrimazole and nystatin, as well as oral azoles, which had previously been effective prior to the advent of HIV, are increasingly only partially effective in OPC in HIV infection. The effectiveness of oral amphotericin B suspension for OPC is described in 17 HIV-infected patients whose response to other therapies had been unsatisfactory. Three patients yielded isolates of Candida albicans with a minimum inhibitory concentration (MIC) to fluconazole of >/=16 microg/mL. Eleven patients received amphotericin B suspension monotherapy. Of the 17 patients, the symptoms of six resolved entirely, seven patients partially responded, and four failed therapy. These data suggest that amphotericin B suspension may be a useful additional therapy for OPC in HIV-infected patients. |
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Authors:
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S Hood; J Evans; J Bond; E Wilkins; D Denning |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AIDS patient care and STDs Volume: 12 ISSN: 1087-2914 ISO Abbreviation: AIDS Patient Care STDS Publication Date: 1998 Aug |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2004-10-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9607225 Medline TA: AIDS Patient Care STDS Country: United States |
Other Details:
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Languages: eng Pagination: 625-7 Citation Subset: X |
Affiliation:
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Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy* Administration, Oral Adult Amphotericin B / administration & dosage, therapeutic use* Antifungal Agents / administration & dosage, therapeutic use* Candidiasis, Oral / drug therapy* Female Humans Male Microbial Sensitivity Tests Middle Aged Suspensions Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Suspensions; 1397-89-3/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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