Document Detail


The treatment of oropharyngeal candidiasis in HIV-infected patients with oral amphotericin B suspension.
MedLine Citation:
PMID:  15468434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oropharyngeal candidiasis (OPC) is the most frequent opportunistic infection associated with HIV infection. Therapies such as topical clotrimazole and nystatin, as well as oral azoles, which had previously been effective prior to the advent of HIV, are increasingly only partially effective in OPC in HIV infection. The effectiveness of oral amphotericin B suspension for OPC is described in 17 HIV-infected patients whose response to other therapies had been unsatisfactory. Three patients yielded isolates of Candida albicans with a minimum inhibitory concentration (MIC) to fluconazole of >/=16 microg/mL. Eleven patients received amphotericin B suspension monotherapy. Of the 17 patients, the symptoms of six resolved entirely, seven patients partially responded, and four failed therapy. These data suggest that amphotericin B suspension may be a useful additional therapy for OPC in HIV-infected patients.
Authors:
S Hood; J Evans; J Bond; E Wilkins; D Denning
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AIDS patient care and STDs     Volume:  12     ISSN:  1087-2914     ISO Abbreviation:  AIDS Patient Care STDS     Publication Date:  1998 Aug 
Date Detail:
Created Date:  2004-09-16     Completed Date:  2004-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9607225     Medline TA:  AIDS Patient Care STDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-7     Citation Subset:  X    
Affiliation:
Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, England.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / drug therapy*
Administration, Oral
Adult
Amphotericin B / administration & dosage,  therapeutic use*
Antifungal Agents / administration & dosage,  therapeutic use*
Candidiasis, Oral / drug therapy*
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Suspensions
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Suspensions; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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