Document Detail

The treatment of meningitis in infants with co-trimoxazole administered parenterally.
MedLine Citation:
PMID:  1064918     Owner:  NLM     Status:  MEDLINE    
We found that co-trimoxazole had a good clinical and antibacterial effect when given parenterally to infants with infections of the central nervous system. We showed good concentrations in the serum and satisfactory penetrations into the cerebrospinal fluid. In one case, there was a side effect which may have been due to the sulpha or to the solvent. We think that at present the preparation should not be given to very premature babies or to babies with icterus, for the same reasons that we avoid using sulpha preparations in these conditions, but otherwise it may be of great use in difficult cases of meningitis caused by Gram-negative bacteria in infancy.
K G Sabel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases. Supplementum     Volume:  -     ISSN:  0300-8878     ISO Abbreviation:  Scand J Infect Dis Suppl     Publication Date:  1976  
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0251025     Medline TA:  Scand J Infect Dis Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / drug therapy*
Drug Combinations
Drug Evaluation
Follow-Up Studies
Infant, Newborn
Injections, Intravenous
Meningitis / drug therapy*
Sulfamethoxazole / administration & dosage,  therapeutic use*
Trimethoprim / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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