Document Detail

The treatment of hypertension in patients with erectile dysfunction.
MedLine Citation:
PMID:  11329820     Owner:  NLM     Status:  MEDLINE    
Hypertension is another predictor of erectile dysfunction (ED). This is further evidence supporting a link between the pathogenesis of atherosclerotic disease and ED. In one study (TOMHS) involving hypertensive patients, the incidence of ED was 14.4%. The drugs used to treat hypertension may cause ED. However, there is little trial-based evidence to indicate which drugs are more likely to cause this side effect. In general, thiazide diuretics and beta-blockers seem to cause ED more often. In contrast, the alpha-blocker, doxazosin, has not been associated with an increased incidence of ED as a side effect. Doxazosin also improves urinary flow in patients with benign prostatic hyperplasia (BPH). This condition is common in elderly men as is hypertension and ED. Therefore, doxazosin may present a special advantage among this group of patients. This alpha-blocker would also be a good choice in patients with impaired glucose tolerance/diabetes because it improves insulin sensitivity. Moreover, ED and hypertension are more prevalent among diabetics. On a more speculative note, doxazosin may potentiate the therapeutic impact of specific treatments for ED.
D P Mikhailidis; M A Khan; H J Milionis; R J Morgan
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medical research and opinion     Volume:  16 Suppl 1     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2000  
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  s31-6     Citation Subset:  IM    
Department of Urology, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK.
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MeSH Terms
Antihypertensive Agents / adverse effects*,  therapeutic use
Diabetes Complications
Doxazosin / pharmacology,  therapeutic use
Erectile Dysfunction / chemically induced,  complications,  prevention & control*
Hypertension / complications,  drug therapy*
Phosphodiesterase Inhibitors / therapeutic use
Piperazines / therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; 74191-85-8/Doxazosin

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