| The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial. | |
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MedLine Citation:
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PMID: 2688125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated an anti-inflammatory enzyme drug Danzen (Serrapeptase: Takeda Chemical Industries, Ltd.) on 70 patients complaining of breast engorgement. These patients were randomly divided into 2 groups, a treatment group and a placebo group. A single observer, unaware of the group the patients were in, assessed the severity of each of the symptoms and signs of breast engorgement before treatment was commenced, and daily for 3 days, during which therapy was administered. Danzen was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving Danzen had "Moderate to Marked" improvement, only 60.0% of the patients receiving placebo had a similar degree of improvement. "Marked" improvement was found in 22.9% of the treatment group and 2.9% of the placebo group. These differences were statistically significant (P less than 0.05). No adverse reactions were reported with the use of Danzen. Danzen is a safe and effective method for the treatment of breast engorgement. |
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Authors:
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W H Kee; S L Tan; V Lee; Y M Salmon |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Singapore medical journal Volume: 30 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1990-01-19 Completed Date: 1990-01-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 48-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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therapeutic use* Breast Feeding* Double-Blind Method Female Humans Lactation / drug effects* Peptide Hydrolases / therapeutic use* Pregnancy Puerperal Disorders / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; EC 3.4.-/Peptide Hydrolases; EC 3.4.-/serratiopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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