Document Detail

The treatment of alcohol and opioid dependence in pregnant women.
MedLine Citation:
PMID:  23037965     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: This article addresses the question of 'best treatment options', which clinicians face when treating pregnant women with alcohol and opioid dependence.
RECENT FINDINGS: Studies show that alcohol consumption is associated with fetal abnormalities and long-term cognitive problems depending on the amount consumed, drinking pattern, and time of gestation. Screening and evaluation of specific interventions are important to reduce alcohol consumption during pregnancy and associated problems in infants. Opioid detoxification is only recommended beyond the first trimester and only in those pregnant women who refuse opioid maintenance therapy. Methadone is the most established treatment of pregnant opioid-dependent women, though recent results indicate some advantages of buprenorphine, slow-release oral methadone and diamorphine compared with methadone.
SUMMARY: Benzodiazepines seem to be the most recommendable option for managing alcohol withdrawal, and psychosocial interventions succeed in reducing alcohol consumption or in maintaining abstinence in alcohol-dependent pregnant women. Regarding opioid dependence, current results suggest that factors like the health status of the mother, the need for additional medications (e.g. treatment for HIV), comorbid drug dependence, and concurrent drug use need to be considered in order to find the 'best opioid substitute'.
Annemarie Heberlein; Lorenzo Leggio; Dirk Stichtenoth; Thomas Hillemacher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in psychiatry     Volume:  25     ISSN:  1473-6578     ISO Abbreviation:  Curr Opin Psychiatry     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809880     Medline TA:  Curr Opin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
aDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research (CARe), Hannover Medical School, Hannover, Germany bCenter for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA cDepartment of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.
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