Document Detail


Is treatment of acute otitis media with once-a-day amoxicillin feasible? Results of a pilot study.
MedLine Citation:
PMID:  8258205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a study of the feasibility of once-a-day amoxicillin to treat acute otitis media (AOM). Seventy-seven children between ages 7 months and 12 years with AOM participated in a double-blind, placebo-controlled trial. Subjects received amoxicillin 40 mg/kg/day for 10 days. They were similar in age, sex, history of ear infections, and presenting symptoms. Group I received one total dose of amoxicillin and two doses of placebo daily. Group II received three divided doses of amoxicillin daily. Parents kept a daily diary of symptoms related to the child's illness and possible medication side effects. Ten children were lost to follow-up. In the remaining 67, pneumatic otoscopy and tympanometry after 10 to 14 days revealed that AOM had resolved in 82% of group I and 68% of group II. Groups showed no significant differences in persistence of middle ear effusion; 39% in group I and 24% in group II still had fluid. Diaries showed no significant differences between groups in medication side effects. Thus, reduced-frequency dosing for AOM seems feasible and more realistic than current regimens.
Authors:
J R Murph; L B Dusdieker; B Booth; W E Murph
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pediatrics     Volume:  32     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-34     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Iowa, Iowa City 52242-1083.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amoxicillin / administration & dosage*,  adverse effects
Child
Child, Preschool
Double-Blind Method
Drug Administration Schedule
Feasibility Studies
Female
Humans
Infant
Male
Otitis Media / diagnosis,  drug therapy*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
RR59/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
26787-78-0/Amoxicillin
Comments/Corrections
Comment In:
Clin Pediatr (Phila). 1995 Mar;34(3):175   [PMID:  7774150 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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