| A trauma-like elevation of plasma cytokines in humans in response to treadmill running. | |
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MedLine Citation:
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PMID: 9824725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Elevated levels of cytokines, especially interleukin (IL)-6 and IL-1ra, can be measured in the plasma of athletes after exhaustive long term exercise. 2. The present study investigates the kinetics of several cytokines and chemokines in ten male athletes before, during and after 2.5 h of treadmill running at 75 % of maximal oxygen consumption (VO2,max). Blood was sampled before, every half-hour during running and every hour in the following 6 h recovery period. 3. The plasma concentration of IL-6 increased after 30 min of running, and peaked at the end of running with a 25-fold increase compared with the pre-exercise value. IL-1ra increased only after running, and peaked after 2 h of rest with an 18-fold increase compared with the pre-exercise value. No changes were found in the concentrations of IL-1beta, tumour necrosis factor (TNF)alpha, IL-15 and macrophage inflammatory protein (MIP)-1beta, and the concentrations of IL-8 and MIP-1alpha were below detection limits. 4. The results suggest that very early events in exercise trigger the release of IL-6, and that the cytokine response to exercise has similarities to that observed after trauma. |
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Authors:
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K Ostrowski; C Hermann; A Bangash; P Schjerling; J N Nielsen; B K Pedersen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 513 ( Pt 3) ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-03 Completed Date: 1999-03-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 889-94 Citation Subset: IM |
Affiliation:
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The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen and Department of Infectious Diseases M, Rigshospitalet, Copenhagen Denmark.ko@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemokine CCL3 Chemokine CCL4 Chemokines / blood Cytokines / blood* Humans Interleukin-1 / blood Interleukin-6 / blood Kinetics Macrophage Inflammatory Proteins / blood Male Middle Aged Oxygen Consumption Running / physiology* Tumor Necrosis Factor-alpha / metabolism Wounds and Injuries / blood* |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL3; 0/Chemokine CCL4; 0/Chemokines; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Macrophage Inflammatory Proteins; 0/Tumor Necrosis Factor-alpha |
| Comments/Corrections | |
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