Document Detail


The transsynovial distribution of oxaprozin.
MedLine Citation:
PMID:  2801338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxaprozin (Wy-21743) is a novel and unique compound among NSAIDs: it bears an aliphatic propionic acid function as a side chain in contrast to the large group of acetic acids and profens. The transsynovial distribution was studied in 18 RA-patients, who required articular surgery. Following a wash-out period of 7 days they were treated with 2 x 600 mg of oxaprozin. The patients were assigned to four different groups representing different treatment duration (2, 3, 4 and 5 days). 12 hours after the last dose during surgery synovial fluid and synovial tissue specimen were removed. Blood samples were taken simultaneously and analysed for oxaprozin employing HPLC. In the synovial tissue samples concentrations of 27 micrograms/g were detected. The concentrations were considerably higher than blood (10-17 micrograms/ml) or synovial fluid (4.9-7.6 micrograms/ml) levels. Oxaprozin shows a different pattern of transsynovial distribution and tissue affinity as compared to other NSAIDs.
Authors:
M Kurowski; H Thabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  27     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-11-09     Completed Date:  1989-11-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  458-60     Citation Subset:  IM    
Affiliation:
Institut für Pharmakologie, Universität Erlangen, FRG.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
Arthritis, Rheumatoid / metabolism,  pathology
Female
Humans
Male
Middle Aged
Propionates / pharmacokinetics*
Propionic Acids / pharmacokinetics*,  pharmacology
Synovial Fluid / metabolism*
Synovial Membrane / metabolism
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Propionates; 0/Propionic Acids; 21256-18-8/oxaprozin; 33005-95-7/tiaprofenic acid

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