Document Detail


The transport of neurotransmitters into synaptic vesicles.
MedLine Citation:
PMID:  7568887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using selection in the neurotoxin MPP+, we have isolated a cDNA encoding vesicular amine transport. The transporter protects against MPP+ by sequestering the toxin in vesicles, away from its primary site of action in mitochondria. Unexpectedly, two distinct but highly related genes encode vesicular amine transport in the adrenal gland and the central nervous system. The sequence of both predicts twelve transmembrane domains and weak homology to a class of bacterial antibiotic resistance proteins. The two human genes occur on different chromosomes. In addition, the two transporters show a number of differences in function, including substrate specificity and the interaction with one inhibitor and the amphetamines.
Authors:
D Peter; Y Liu; N Brecha; R H Edwards
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in brain research     Volume:  105     ISSN:  0079-6123     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-81     Citation Subset:  IM    
Affiliation:
Department of Neurology, UCLA School of Medicine, 90024-1769, USA.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenylpyridinium / pharmacology
Animals
Biological Transport / physiology
Drug Resistance
Neurotransmitter Agents / physiology*
Synaptic Vesicles / physiology*
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 48134-75-4/1-Methyl-4-phenylpyridinium

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