Document Detail


The transport of alpha-tocopherol and beta-carotene in human blood.
MedLine Citation:
PMID:  181502     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentrations and distributions of major lipids (cholesterol, phospholipid, and triglyceride), tocopherol and carotenoids were determined in the plasma lipoprotein fractions (VLDL, LDL, and HDL) of (1) normal human subjects, (2) patients with hyperlipoproteinemia, and (3) patients with erythropoietic protoporphyria treated with oral beta-carotene and/or alpha-tocopherol. The distribution of tocopherol (in percent) was most closely correlated with the distribution of total lipids in the individual lipoproteins, while the major portion of beta-carotene was present in the low density lipoproteins, irrespective of the lipid distribution in the lipoproteins (except for one subject with hyperchylomicronemia). The alpha-tocopherol and beta-carotene concentrations of plasma and RBC in patients treated with tocopherol and carotene were determined periodically for a one-year period. Plasma and RBC tocopherol concentrations showed a rapid, parallel increase in response to tocopherol supplementation. In contrast, the plasma and RBC carotene concentrations showed a much slower and nonparallel increase in response to carotene administration. When carotene supplementation was stopped, the elevated carotene levels in both plasma and RBC persisted for several months; the elevated plasma carotene level persisted longer than the raised RBC carotene levels. These results suggest that alpha-tocopherol and beta-carotene are transported differently in the circulation and that the tissue storage and mobilization of these compounds are different.
Authors:
L K Bjornson; H J Kayden; E Miller; A N Moshell
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  17     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Transport
Carotenoids / blood*,  therapeutic use
Cholesterol / blood
Female
Humans
Hyperlipidemias / blood
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Male
Middle Aged
Phospholipids / blood
Porphyrias / blood,  drug therapy
Triglycerides / blood
Vitamin E / blood*,  therapeutic use
Chemical
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Phospholipids; 0/Triglycerides; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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