Document Detail

The transplacental transfer of IgG subclasses: influence of prematurity and low birthweight in the Gambian population.
MedLine Citation:
PMID:  12530282     Owner:  NLM     Status:  MEDLINE    
Having established previously that prematurity in The Gambia is associated with impaired maternofetal transfer of some specific antibodies, we investigated the influence of low birthweight and prematurity on placental transfer of IgG subclasses in 180 Gambian mothers and their newborn babies. A physician-blinded, cross-sectional study of 180 mother-baby pairs was carried out in the labour ward of Bansang Hospital, The Gambia. Paired maternal and cord serum samples were collected from mothers and their newborns. Serum IgG subclass levels were measured by laser nephelometry. Placental transfer of all IgG subclasses was significantly reduced in preterm newborns compared with term newborns (p < 0.01). In low birthweight (LBW) babies, the transfer of IgG1 (p = 0.03) and IgG2 (p < 0.01) subclasses, but not IgG3 and IgG4, was significantly reduced. In preterm neonates with an adequate birthweight and term neonates with a low birthweight, all IgG subclasses were transferred with reduced efficiency, but IgG1 and IgG2 subclasses were transferred with significantly less efficiency than IgG3 and IgG4. These results confirm that prematurity and low birthweight are associated with impaired placental transfer of IgG1 and IgG2 subclasses in this Gambian population. This impairment might explain the susceptibility of these newborns to certain polysaccharide-encapsulated organisms.
B J Okoko; H L Wesumperuma; J Fern; L K Yamuah; C A Hart
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  22     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Medical Research Council, Fajara, The Gambia, PO Box 273, Banjul, The Gambia, West Africa.
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MeSH Terms
Cross-Sectional Studies
Fetal Blood / immunology
Immunoglobulin G / blood*,  immunology
Infant, Low Birth Weight / blood*,  immunology
Infant, Newborn
Infant, Premature / blood*,  immunology
Maternal-Fetal Exchange / immunology*
Middle Aged
Reg. No./Substance:
0/Immunoglobulin G

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