Document Detail

Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?
MedLine Citation:
PMID:  23162448     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The orexin/hypocretin (Orx/Hcrt) system has long been considered to regulate a wide range of physiological processes, including feeding, energy metabolism, and arousal. More recently, concordant observations have demonstrated an important role for these peptides in the reinforcing properties of most drugs of abuse. Orx/Hcrt neurons arise in the lateral hypothalamus (LH) and project to all brain structures implicated in the regulation of arousal, stress, and reward. Although Orx/Hcrt neurons have been shown to massively project to the paraventricular nucleus of the thalamus (PVT), only recent evidence suggested that the PVT may be a key relay of Orx/Hcrt-coded reward-related communication between the LH and both the ventral and dorsal striatum. While this thalamic region was not thought to be part of the "drug addiction circuitry," an increasing amount of evidence demonstrated that the PVT-particularly PVT Orx/Hcrt transmission-was implicated in the modulation of reward function in general and several aspects of drug-directed behaviors in particular. The present review discusses recent findings that suggest that maladaptive recruitment of PVT Orx/Hcrt signaling by drugs of abuse may promote persistent compulsive drug-seeking behavior following a period of protracted abstinence and as such may represent a relevant target for understanding the long-term vulnerability to drug relapse after withdrawal.
Rémi Martin-Fardon; Benjamin Boutrel
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Publication Detail:
Type:  Journal Article     Date:  2012-11-09
Journal Detail:
Title:  Frontiers in behavioral neuroscience     Volume:  6     ISSN:  1662-5153     ISO Abbreviation:  Front Behav Neurosci     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-19     Completed Date:  2012-11-20     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477952     Medline TA:  Front Behav Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  75     Citation Subset:  -    
Molecular and Integrative Neurosciences Department, The Scripps Research Institute La Jolla, CA, USA.
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