Document Detail

The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster.
MedLine Citation:
PMID:  15654626     Owner:  NLM     Status:  MEDLINE    
We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
Yuki Hirota; Kazunobu Sawamoto; Kuniaki Takahashi; Ryu Ueda; Hideyuki Okano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-15
Journal Detail:
Title:  Development genes and evolution     Volume:  215     ISSN:  0949-944X     ISO Abbreviation:  Dev. Genes Evol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9613264     Medline TA:  Dev Genes Evol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  90-6     Citation Subset:  IM    
Department of Physiology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Cell Differentiation
Drosophila Proteins / genetics,  physiology*
Drosophila melanogaster / embryology*,  genetics,  growth & development
Eye / cytology,  embryology*,  growth & development
Membrane Proteins / genetics,  physiology*
RNA Interference
RNA, Messenger / analysis,  metabolism
Reg. No./Substance:
0/Drosophila Proteins; 0/Membrane Proteins; 0/RNA, Messenger; 0/tincar protein, Drosophila

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