| The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes. | |
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MedLine Citation:
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PMID: 19703420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport. We show here that NDC1 directly interacts with the nucleoporin ALADIN, mutations of which are responsible for triple-A syndrome, and that this interaction is required for targeting of ALADIN to nuclear pore complexes (NPCs). Furthermore, we show that NDC1 is required for selective nuclear import. Our findings suggest that NDC1-mediated localization of ALADIN to NPCs is essential for selective nuclear protein import, and that abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome. |
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Authors:
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Yusuke Yamazumi; Atsushi Kamiya; Ayumu Nishida; Ayako Nishihara; Shun-Ichiro Iemura; Tohru Natsume; Tetsu Akiyama |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-22 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 389 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 100-4 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Bioscience, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Active Transport, Cell Nucleus Hela Cells Humans Nerve Tissue Proteins / genetics, metabolism* Nuclear Pore / metabolism* Nuclear Pore Complex Proteins / genetics, metabolism* RNA Interference |
| Chemical | |
Reg. No./Substance:
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0/AAAS protein, human; 0/Nerve Tissue Proteins; 0/Nuclear Pore Complex Proteins; 0/TMEM48 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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