| The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia. | |
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MedLine Citation:
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PMID: 1736569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether short periods of preconditioning ischemia limited infarct size in a model of low coronary collateral flow and whether the effects of preconditioning were transient or long-lasting. Rats underwent 90 minutes of coronary occlusion followed by reperfusion. In one group, the rats were preconditioned by three 3-minute occlusions, each separated by 5 minutes of reperfusion. The size of the myocardial infarcts were smaller in the preconditioned group (24.9 +/- 7.8% of the risk zone developed necrosis) versus the nonpreconditioned group (60.7 +/- 5.3%, p less than 0.01). In addition, the incidence of ventricular arrhythmias was reduced by preconditioning. However, when there was a delay of 1 hour or more between the brief episodes of preconditioning and the longer 90-minute occlusion, the beneficial effects of preconditioning were lost. Thus preconditioning reduced the volume of myocardium infarcted and the incidence of ventricular arrhythmias during a subsequent period of prolonged ischemia; however, these beneficial effects were transient. |
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Authors:
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Y W Li; P Whittaker; R A Kloner |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 123 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-06 Completed Date: 1992-03-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 346-53 Citation Subset: AIM; IM |
Affiliation:
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Heart Institute, Hospital of the Good Samaritan, Los Angeles, CA 90017. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / prevention & control* Collateral Circulation / physiology Constriction Coronary Circulation / physiology Coronary Disease / physiopathology Electrocardiography Female Myocardial Infarction / pathology* Myocardial Reperfusion Injury / pathology, prevention & control* Myocardium / pathology Rats Rats, Inbred Strains Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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