Document Detail

The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia.
MedLine Citation:
PMID:  1736569     Owner:  NLM     Status:  MEDLINE    
We sought to determine whether short periods of preconditioning ischemia limited infarct size in a model of low coronary collateral flow and whether the effects of preconditioning were transient or long-lasting. Rats underwent 90 minutes of coronary occlusion followed by reperfusion. In one group, the rats were preconditioned by three 3-minute occlusions, each separated by 5 minutes of reperfusion. The size of the myocardial infarcts were smaller in the preconditioned group (24.9 +/- 7.8% of the risk zone developed necrosis) versus the nonpreconditioned group (60.7 +/- 5.3%, p less than 0.01). In addition, the incidence of ventricular arrhythmias was reduced by preconditioning. However, when there was a delay of 1 hour or more between the brief episodes of preconditioning and the longer 90-minute occlusion, the beneficial effects of preconditioning were lost. Thus preconditioning reduced the volume of myocardium infarcted and the incidence of ventricular arrhythmias during a subsequent period of prolonged ischemia; however, these beneficial effects were transient.
Y W Li; P Whittaker; R A Kloner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  123     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-06     Completed Date:  1992-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-53     Citation Subset:  AIM; IM    
Heart Institute, Hospital of the Good Samaritan, Los Angeles, CA 90017.
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MeSH Terms
Arrhythmias, Cardiac / prevention & control*
Collateral Circulation / physiology
Coronary Circulation / physiology
Coronary Disease / physiopathology
Myocardial Infarction / pathology*
Myocardial Reperfusion Injury / pathology,  prevention & control*
Myocardium / pathology
Rats, Inbred Strains
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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