Document Detail

The transient hypercholesterolemia of major weight loss.
MedLine Citation:
PMID:  2035468     Owner:  NLM     Status:  MEDLINE    
Serum lipoproteins, body composition, and adipose cholesterol contents of six obese women were studied during and after major weight loss by very-low-calorie diets (VLCDs). Subjects started at 168 +/- 11% of ideal body weight, lost 30.3 +/- 3.7 kg in 5-7 mo, followed by 2+ mo in weight maintenance. Serum cholesterol fell from a prediet (baseline) value of 5.49 +/- 0.32 to 3.62 +/- 0.31 mmol/L (P less than 0.01) after 1-2 mo of VLCDs (nadir), after which it rose to 5.95 +/- 0.36 mmol/L (peak, P less than 0.01 compared with nadir and baseline) as weight loss continued. With weight maintenance, serum cholesterol fell to 4.92 +/- 0.34 mmol/L (P less than 0.05 compared with peak). Adipose cholesterol content did not change in peripheral (arm and leg) biopsy sites but rose significantly in abdominal adipose tissue with weight loss. We conclude that major weight loss was associated with a late rise in serum cholesterol, possibly from mobilization of adipose cholesterol stores, which resolved when weight loss ceased.
S D Phinney; A B Tang; C R Waggoner; R G Tezanos-Pinto; P A Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-21     Completed Date:  1991-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1404-10     Citation Subset:  AIM; IM    
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MeSH Terms
Adipose Tissue / chemistry
Analysis of Variance
Body Composition
Cholesterol / analysis,  blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Diet, Reducing*
Energy Intake
Hypercholesterolemia / etiology*
Obesity / blood,  diet therapy*
Weight Loss / physiology*
Grant Support
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol

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