Document Detail


A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats.
MedLine Citation:
PMID:  17804584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic baroreflex sensitivity (BRS). AP and RSNA were simultaneously recorded in conscious rats, either baroreceptor-intact (control, n = 11) or with partial denervation of baroreflex afferents [aortic baroreceptor denervated (ABD; n = 10)] during 1-h periods of spontaneous activity. Transfer gain was calculated over 58 adjacent 61.4-s periods (segmented into 10.2-s periods). Coherence between AP and RSNA was statistically (P < 0.05) significant in 90 +/- 3% and 56 +/- 10% of cases in control and ABD rats, respectively. Transfer gain was higher (P = 0.0049) in control [2.39 +/- 0.13 normalized units (NU)/mmHg] than in ABD (1.48 +/- 0.22 NU/mmHg) rats. In the pooled study sample, transfer gain correlated with sympathetic BRS estimated by the vasoactive drug injection technique (R = 0.75; P < 0.0001) and was inversely related to both time- (standard deviation; R = -0.74; P = 0.0001) and frequency-domain [total spectral power (0.00028-2.5 Hz); R = -0.82; P < 0.0001] indices of AP variability. In control rats, transfer gain exhibited large fluctuations (coefficient of variation: 34 +/- 3%) that were not consistently related to changes in the mean level of AP, heart rate, or RSNA. In conclusion, the transfer function method provides a continuous, functionally relevant index of sympathetic BRS and reveals that the latter fluctuates widely over time.
Authors:
Roy Kanbar; Valérie Oréa; Bruno Chapuis; Christian Barrès; Claude Julien
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Publication Detail:
Type:  Journal Article     Date:  2007-09-05
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1938-46     Citation Subset:  IM    
Affiliation:
Université de Lyon, France. roy.kanbar@sante.univ-lyon1.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / physiology*
Blood Pressure / physiology
Data Interpretation, Statistical
Denervation
Heart Rate / physiology
Kidney / innervation*,  physiology*
Kidney Function Tests
Male
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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