Document Detail


Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor.
MedLine Citation:
PMID:  21145493     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The mitochondrial gateway to cell death is a frequent target for tumor suppressors, which largely utilize Bcl-2-dependent apoptotic pathways. Reporting in Science, Giorgi et al. (2010) now show that PML exerts its tumor suppressor function via a distinct mechanism: Ca²(+) transfer from the endoplasmic reticulum to the mitochondria.
Authors:
Aleck W E Jones; Gyorgy Szabadkai
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  19     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  789-90     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, UK.
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Comment On:
Science. 2010 Nov 26;330(6008):1247-51   [PMID:  21030605 ]

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