Document Detail


In vitro transdermal and biological evaluation of ALA-loaded poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide-co-acrylic acid) microgels for photodynamic therapy.
MedLine Citation:
PMID:  22494064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Poly(N-isopropylacrylamide) (PNIPA) and Poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPA-co-AA)) microgels loaded with 5-aminolevulinic acid (ALA) were prepared by the spray-drying method. The amount of drug loaded was 290 µg ALA/mg microgel for PNIPA and 244 µg ALA/mg microgel for P(NIPA-co-AA) microgels. Maximum in vitro drug release took place within 15-30 min for PNIPA and 1-1.5 h for P(NIPA-co-AA) microgels as a function of pH, at 37°C. Transdermal delivery from microgels showed permeation fluxes 10 times higher than the passive diffusion flux. The cytotoxicity of microgels synthesized in HeLa cells after the application of photodynamic therapy (PDT) was superior compared with the administration of ALA in solution alone. Finally, the use of these microgels as a delivery vehicle for ALA constitutes a system capable of enhancing its topical administration and PDT effectiveness.
Authors:
Clara Gómez; Marta Benito; Issa Katime; José María Teijón; María Dolores Blanco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-12
Journal Detail:
Title:  Journal of microencapsulation     Volume:  29     ISSN:  1464-5246     ISO Abbreviation:  J Microencapsul     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-04-03     Revised Date:  2014-01-22    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  England    
Other Details:
Languages:  eng     Pagination:  626-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylamides / pharmacology*
Administration, Cutaneous
Aminolevulinic Acid / pharmacology*
Animals
Drug Delivery Systems*
Drug Evaluation, Preclinical
HeLa Cells
Humans
Photochemotherapy / methods*
Photosensitizing Agents / pharmacology*
Polymers / pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Acrylamides; 0/N-isopropylacrylamide-acrylic acid copolymer; 0/Photosensitizing Agents; 0/Polymers; 25189-55-3/poly-N-isopropylacrylamide; 88755TAZ87/Aminolevulinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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