| The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. | |
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MedLine Citation:
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PMID: 15203319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bright is an ARID family transcription factor that increases immunoglobulin heavy chain transcription. In the mouse, Bright expression is tightly regulated and B cell-restricted and the Bright protein associates with Bruton's tyrosine kinase (Btk), the defective enzyme in X-linked immunodeficiency. Human X-linked agammaglobulinemia results from defects in Btk and leads to early blocks in B lymphocyte development. Because so little is known about human Bright, we sought to determine where human Bright is expressed in normal B cell differentiation and whether it also forms complexes with Btk. Although human and mouse Bright exhibited similar expression patterns in normal B cells, many human transformed B cell lines did not express Bright protein. However, the human protein bound prototypic Bright DNA-binding motifs and, like mouse Bright, was capable of associating with Btk. These data suggest potentially important similarities exist in Bright expression and activity in human and mouse B lymphocytes. |
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Authors:
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Jamee C Nixon; Jaya B Rajaiya; Neil Ayers; Seth Evetts; Carol F Webb |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cellular immunology Volume: 228 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-06-18 Completed Date: 2004-07-30 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 42-53 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocyte Subsets
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metabolism* Base Sequence Binding Sites Cell Line, Transformed Consensus Sequence DNA / chemistry, metabolism DNA-Binding Proteins / genetics, metabolism* Gene Expression Germinal Center / metabolism Humans Oncogenes / genetics Protein-Tyrosine Kinases / metabolism Stem Cells / metabolism Tissue Distribution Trans-Activators / genetics, metabolism* Transcription Factors / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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07633//PHS HHS; 44215//PHS HHS; AI45864/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ARID3A protein, human; 0/DNA-Binding Proteins; 0/Trans-Activators; 0/Transcription Factors; 9007-49-2/DNA; EC 2.7.10.1/Agammaglobulinaemia tyrosine kinase; EC 2.7.10.1/Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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