Document Detail

The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.
MedLine Citation:
PMID:  15203319     Owner:  NLM     Status:  MEDLINE    
Bright is an ARID family transcription factor that increases immunoglobulin heavy chain transcription. In the mouse, Bright expression is tightly regulated and B cell-restricted and the Bright protein associates with Bruton's tyrosine kinase (Btk), the defective enzyme in X-linked immunodeficiency. Human X-linked agammaglobulinemia results from defects in Btk and leads to early blocks in B lymphocyte development. Because so little is known about human Bright, we sought to determine where human Bright is expressed in normal B cell differentiation and whether it also forms complexes with Btk. Although human and mouse Bright exhibited similar expression patterns in normal B cells, many human transformed B cell lines did not express Bright protein. However, the human protein bound prototypic Bright DNA-binding motifs and, like mouse Bright, was capable of associating with Btk. These data suggest potentially important similarities exist in Bright expression and activity in human and mouse B lymphocytes.
Jamee C Nixon; Jaya B Rajaiya; Neil Ayers; Seth Evetts; Carol F Webb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cellular immunology     Volume:  228     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-07-30     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-53     Citation Subset:  IM    
Department of Microbiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
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MeSH Terms
B-Lymphocyte Subsets / metabolism*
Base Sequence
Binding Sites
Cell Line, Transformed
Consensus Sequence
DNA / chemistry,  metabolism
DNA-Binding Proteins / genetics,  metabolism*
Gene Expression
Germinal Center / metabolism
Oncogenes / genetics
Protein-Tyrosine Kinases / metabolism
Stem Cells / metabolism
Tissue Distribution
Trans-Activators / genetics,  metabolism*
Transcription Factors / genetics,  metabolism*
Grant Support
07633//PHS HHS; 44215//PHS HHS; AI45864/AI/NIAID NIH HHS
Reg. No./Substance:
0/ARID3A protein, human; 0/DNA-Binding Proteins; 0/Trans-Activators; 0/Transcription Factors; 9007-49-2/DNA; EC tyrosine kinase; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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