Document Detail

The trans-activating C-type retroviruses share a distinct epitope(s) that induces antibodies in certain infected hosts.
MedLine Citation:
PMID:  1716653     Owner:  NLM     Status:  MEDLINE    
Using sera from hosts infected with bovine leukaemia virus (BLV), human T cell lymphoma virus types I and II (HTLV-I and -II), or simian T cell lymphoma virus type I (STLV-I), we found that the major gag proteins of these viruses cross-react immunologically. The specificity of this cross-reactivity was demonstrated by absorption using purified viral proteins, virus lysates and extracts of infected cells. The data strongly suggested that the cross-reacting epitope(s), referred to as CE, differs from those responsible for cross-reactions between the major gag proteins of HTLV-I, HTLV-II and STLV-I, and between those of BLV and HTLV-I reported previously. The prevalence of antibodies to CE was low, even amongst infected hosts with high titres to other epitopes present in the major gag proteins of the homologous viruses. CE was not detected in any of the other C- or D-type retroviruses, or lentiviruses examined. Therefore, it is likely that CE can be used to define serologically a subgroup of C-type retroviruses, the genomes of which display unique features and functional activities.
R O Zandomeni; M Carrera-Zandomeni; E Esteban; J F Ferrer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  72 ( Pt 9)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-18     Completed Date:  1991-10-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2113-9     Citation Subset:  IM; X    
School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348.
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MeSH Terms
Antibodies, Viral / biosynthesis
Antigens, Viral / immunology*
Blotting, Western
Cross Reactions
Epitopes / analysis,  immunology
Gene Products, gag / immunology
Human T-lymphotropic virus 1 / immunology*
Human T-lymphotropic virus 2 / immunology*
Leukemia Virus, Bovine / immunology*
Pan troglodytes
Precipitin Tests
Simian T-lymphotropic virus 1 / immunology*
Transcriptional Activation
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Epitopes; 0/Gene Products, gag

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