Document Detail

trans-Resveratrol in nutraceuticals: issues in retail quality and effectiveness.
MedLine Citation:
PMID:  23090020     Owner:  NLM     Status:  MEDLINE    
Fourteen brands of resveratrol-containing nutraceuticals were evaluated in order to verify their actual resveratrol content and to control if their health-promoting properties are related to manufacturing quality. Products included pure resveratrol capsules or multi-ingredient formulations with standardized amounts of resveratrol and other phytochemicals. Samples were analyzed for total trans-resveratrol, flavonoids, procyanidin, polyphenol content and the results were compared with the content declared on-label. Only five out of 14 brands had near label values, compliant with Good Manufacturing Practices (GMP) requirements (95-105% content of active constituent), four products were slightly out of this range (83-111%) and three were in the 8-64% range. Two samples were below the limit of detection. The greater the difference between actual and labeled resveratrol content, the lower was the antioxidant and antiproliferative activity strength. Dietary supplements containing pure trans-resveratrol exhibited a greater induction of differentiation towards human leukemic K562 cells when compared to multicomponent products. Great differences currently exist among resveratrol food supplements commercially available and GMP-grade quality should not be taken for granted. On the other side, dosages suggested by most "pure", "high-dosage" supplements may allow a supplementation level adequate to obtain some of the purported health benefits.
Damiano Rossi; Alessandra Guerrini; Renato Bruni; Eleonora Brognara; Monica Borgatti; Roberto Gambari; Silvia Maietti; Gianni Sacchetti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-22
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  17     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-08-13     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  12393-405     Citation Subset:  IM    
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MeSH Terms
Antioxidants / analysis
Biflavonoids / analysis
Catechin / analysis
Cell Differentiation / drug effects
Cell Proliferation / drug effects
Chromatography, High Pressure Liquid
Commerce / standards*
Dietary Supplements / standards*
Discriminant Analysis
Erythroid Cells / cytology,  drug effects,  metabolism
Flavonoids / analysis
Food Labeling
K562 Cells
Least-Squares Analysis
Polyphenols / analysis
Proanthocyanidins / analysis
Stilbenes / pharmacology,  standards*
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Biflavonoids; 0/Flavonoids; 0/Polyphenols; 0/Proanthocyanidins; 0/Stilbenes; 4852-22-6/procyanidin; 8R1V1STN48/Catechin; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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