Document Detail

trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study.
MedLine Citation:
PMID:  17490969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism. OBJECTIVE: The objective was to investigate the relation between trans fatty acids and long-chain polyunsaturates in mature human milk. DESIGN: Human milk samples (n=769) were obtained at the 6th week of lactation from mothers participating in a birth cohort study in Germany. The fatty acid composition of the milk samples was measured by high-resolution capillary gas-liquid chromatography. RESULTS: trans Octadecenoic and trans octadecadienoic acids were inversely correlated with linoleic acid (r=-0.32 and -0.33, P<0.0001 for both), alpha-linolenic acid (r=-0.35 and -0.27, P<0.0001), arachidonic acid (r=-0.60 and -0.47, P<0.0001), and docosahexaenoic acid (r=-0.51 and -0.33, P<0.0001). In contrast, no inverse correlations were observed between trans hexadecenoic acid and polyunsaturated fatty acids. CONCLUSIONS: The data obtained in the present study suggest that the availability of 18-carbon trans isomeric fatty acids may be inversely related to the availability of long-chain polyunsaturated fatty acids in mature human milk.
Eva Szabó; Günther Boehm; Christopher Beermann; Maria Weyermann; Hermann Brenner; Dietrich Rothenbacher; Tamás Decsi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1320-6     Citation Subset:  AIM; IM    
Department of Paediatrics, University of Pécs, Pécs, Hungary.
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MeSH Terms
Chromatography, Gas / methods
Cohort Studies
Fatty Acids, Essential / analysis,  chemistry
Fatty Acids, Omega-3 / analysis
Fatty Acids, Omega-6 / analysis
Fatty Acids, Unsaturated / analysis*,  chemistry
Linolenic Acids / analysis
Milk, Human / chemistry*
Postpartum Period
Stearic Acids / analysis*,  chemistry
Trans Fatty Acids / analysis*,  chemistry
alpha-Linolenic Acid / analysis
Reg. No./Substance:
0/5-octadecenoic acid; 0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Linolenic Acids; 0/Stearic Acids; 0/Trans Fatty Acids; 26764-25-0/octadecadienoic acid; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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