| The trace analysis of alkyl alkylphosphonic acids in urine using gas chromatography-ion trap negative ion tandem mass spectrometry. | |
| | |
MedLine Citation:
|
PMID: 15664357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A sensitive method has been developed for the trace analysis of alkyl alkylphosphonic acids, metabolites of nerve agents, in urine using a benchtop ion trap mass spectrometer. The acids were isolated from urine by simple solid phase extraction and converted to their pentafluorobenzyl esters. An ion trap mass spectrometer in selected reaction monitoring mode provided limits of detection of 0.1 ng/ml for isopropyl, isobutyl, pinacolyl and cyclohexyl methylphosphonic acids and for ethyl ethylphosphonic acid. The detection limit for ethyl methylphosphonic acid was higher (0.5 ng/ml) due to a lower recovery. |
| | |
Authors:
|
James Riches; Ian Morton; Robert W Read; Robin M Black |
Related Documents
:
|
2894957 - Metabolism of 2,3-dichloro-1-propene in the rat. consideration of bioactivation mechani... 8373447 - Induction of 5-oxoprolinuria in the rat following chronic feeding with n-acetyl 4-amino... 3731457 - Normal reference intervals for free catecholamines and their acid metabolites in 24-h u... 17031047 - Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice. 4998247 - Spore refractility in variants of bacillus cereus treated with actinomycin d. 21106917 - Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Volume: 816 ISSN: 1570-0232 ISO Abbreviation: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-24 Completed Date: 2005-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101139554 Medline TA: J Chromatogr B Analyt Technol Biomed Life Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 251-8 Citation Subset: IM |
Affiliation:
|
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 OJQ, UK. jriches@dstl.gov.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Markers / urine Chemical Warfare Agents / analysis* Gas Chromatography-Mass Spectrometry / methods* Humans Macaca mulatta Phosphonic Acids / urine* Sensitivity and Specificity Soman / urine |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Chemical Warfare Agents; 0/Phosphonic Acids; 96-64-0/Soman |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs...
Next Document: Evaluation of immobilized metal membrane affinity chromatography for purification of an immunoglobul...