Document Detail

The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin.
MedLine Citation:
PMID:  6701907     Owner:  NLM     Status:  MEDLINE    
The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a co-teratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.
R G Skalko; P D Poche; T E Kwasigroch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology     Volume:  30     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-24     Completed Date:  1984-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
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MeSH Terms
Caffeine / toxicity*
Drug Interactions
Fetal Death / chemically induced
Fetal Resorption / chemically induced
Mice, Inbred ICR
Phenytoin / toxicity*
Reg. No./Substance:
0/Teratogens; 57-41-0/Phenytoin; 58-08-2/Caffeine

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