| The toxicology of chemical interactions during pregnancy in the mouse: caffeine and phenytoin. | |
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MedLine Citation:
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PMID: 6701907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a co-teratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit. |
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Authors:
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R G Skalko; P D Poche; T E Kwasigroch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology Volume: 30 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-04-24 Completed Date: 1984-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 7-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / toxicity* Drug Interactions Female Fetal Death / chemically induced Fetal Resorption / chemically induced Mice Mice, Inbred ICR Phenytoin / toxicity* Pregnancy Teratogens* |
| Chemical | |
Reg. No./Substance:
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0/Teratogens; 57-41-0/Phenytoin; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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