Document Detail


The toxicology of PCB's--an overview for clinicians.
MedLine Citation:
PMID:  6223449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polychlorinated biphenyls (PCB's) have low acute toxicity but are of public health concern because of their persistence in the environment, the bioaccumulation in human and animal tissues, and their potential for chronic or delayed toxicity. Although many questions remain unanswered, it is clear that occupational exposure, at a minimum, can produce dermatologic effects and liver dysfunction. The long half-life of PCB's and their presence in various human tissues leaves open the possibility of substantial chronic and delayed effects analogous to those seen in animals. PCB's are potent inhibitors of reproductive function in both rodents and nonhuman primates and produce liver tumors in animal cancer bioassays. As potent inducers of hepatic enzyme systems, PCB's may have additional unpredictable long-term health effects. These effects have only recently begun to be studied in a rigorous manner, and although the epidemiological evidence is neither complete nor entirely consistent, there can be no question of the necessity to keep human exposures to the lowest feasible levels.
Authors:
G Letz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Western journal of medicine     Volume:  138     ISSN:  0093-0415     ISO Abbreviation:  West. J. Med.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-08-17     Completed Date:  1983-08-17     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0410504     Medline TA:  West J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  534-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acne Vulgaris / chemically induced
Air Pollutants / toxicity*
Animals
Carcinogens
Chemical Phenomena
Chemistry
Enzyme Induction / drug effects
Female
Humans
Lethal Dose 50
Liver / drug effects
Male
Polychlorinated Biphenyls / metabolism,  toxicity*
Rats
Reproduction / drug effects
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Carcinogens; 0/Polychlorinated Biphenyls
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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