| The toxicokinetics of (1R, cis)- and (1R, trans)- tetramethrin in the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 2750207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The toxicokinetics of cis- and trans-tetramethrin isomers were investigated using the isolated perfused rat liver preparation. 2. The concentration of cis- and trans-tetramethrin decreased rapidly in the plasma perfusate and was initially replaced by N-(hydroxymethyl)3,4,5,6-tetrahydrophthalimide (MTI) and then by 3,4,5,6-tetrahydrophthalimide (TPI). Plasma perfusate concentrations of the intact cis-isomer were higher than those of the trans-isomer. Concentrations of MTI and TPI were higher in livers treated with the trans-isomer. 3. Tetramethrin and its metabolites were rapidly excreted in the bile. Bile from livers perfused with trans-isomer contained higher concentrations of parent isomer and metabolites MTI and TPI, than did bile from livers treated with the cis-isomer. |
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Authors:
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I S Silver; W C Dauterman |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 19 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 509-19 Citation Subset: IM |
Affiliation:
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Toxicology Program, North Carolina State University, Raleigh 27695. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Captan Kinetics Liver / drug effects, metabolism* Male Perfusion Phthalimides / metabolism Pyrethrins / metabolism*, toxicity Rats Rats, Inbred Strains Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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ES-00044/ES/NIEHS NIH HHS; ES-07046/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phthalimides; 0/Pyrethrins; 133-06-2/Captan; 27813-21-4/tetrahydrophthalimide; 7696-12-0/tetramethrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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