| A toxicity study of parenteral thiamine hydrochloride. | |
MedLine Citation:
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PMID: 2757284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thiamine deficiency is not uncommon in certain populations and clinical disease states such as Wernicke's encephalopathy or beriberi. Rapid parenteral repletion may be required, yet questions about the safety of IV thiamine have been raised because of reports of anaphylaxis. Our study was a prospective evaluation of the safety of thiamine hydrochloride given as a 100-mg IV bolus in 989 consecutive patients (1,070 doses). A total of 12 adverse reactions (1.1%) were reported. Minor reactions consisting of transient local irritation were seen in 11 patients (1.02%), and there was only one major reaction (0.093%) consisting of generalized pruritus. Thiamine hydrochloride may be administered intravenously without undue concern. Intradermal test doses before administration are not warranted unless patients have had previous allergic reactions. |
Authors:
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K D Wrenn; F Murphy; C M Slovis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of emergency medicine Volume: 18 ISSN: 0196-0644 ISO Abbreviation: Ann Emerg Med Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-08-28 Completed Date: 1989-08-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 867-70 Citation Subset: AIM; IM |
Affiliation:
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Grady Memorial Hospital, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anaphylaxis / etiology Drug Hypersensitivity / etiology* Female Fluid Therapy Humans Infusions, Intravenous Male Middle Aged Prospective Studies Thiamine / administration & dosage, toxicity* Thiamine Deficiency / drug therapy* |
| Chemical | |
Reg. No./Substance:
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59-43-8/Thiamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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