Document Detail

A toxicity study of parenteral thiamine hydrochloride.
MedLine Citation:
PMID:  2757284     Owner:  NLM     Status:  MEDLINE    
Thiamine deficiency is not uncommon in certain populations and clinical disease states such as Wernicke's encephalopathy or beriberi. Rapid parenteral repletion may be required, yet questions about the safety of IV thiamine have been raised because of reports of anaphylaxis. Our study was a prospective evaluation of the safety of thiamine hydrochloride given as a 100-mg IV bolus in 989 consecutive patients (1,070 doses). A total of 12 adverse reactions (1.1%) were reported. Minor reactions consisting of transient local irritation were seen in 11 patients (1.02%), and there was only one major reaction (0.093%) consisting of generalized pruritus. Thiamine hydrochloride may be administered intravenously without undue concern. Intradermal test doses before administration are not warranted unless patients have had previous allergic reactions.
K D Wrenn; F Murphy; C M Slovis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  18     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-28     Completed Date:  1989-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  867-70     Citation Subset:  AIM; IM    
Grady Memorial Hospital, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303.
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MeSH Terms
Aged, 80 and over
Anaphylaxis / etiology
Drug Hypersensitivity / etiology*
Fluid Therapy
Infusions, Intravenous
Middle Aged
Prospective Studies
Thiamine / administration & dosage,  toxicity*
Thiamine Deficiency / drug therapy*
Reg. No./Substance:

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