Document Detail


The toxic oil syndrome: an example of an exogenously induced autoimmune reaction. Toxic oil syndrome.
MedLine Citation:
PMID:  9112238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The toxic oil syndrome (TOS) is a chemically induced autoimmune-like reaction in humans. The etiologic agent(s) have so far not clearly been identified. A short overview is given on this disease which is associated with a unique antibody specificity to cryptic epitopes of C-reactive protein in affected patients. In addition a murine model for TOS is described which suggests that genetic susceptibility might play a role in inducing a similar syndrome in mice. These differences are reflected in the immunological alterations and cytokine production caused by the toxicant.
Authors:
S A Bell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular biology reports     Volume:  23     ISSN:  0301-4851     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  1996  
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ludwig-Maximilians-University Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aniline Compounds / poisoning
Animals
Autoantibodies / immunology
Autoimmune Diseases / chemically induced,  immunology*
Autoimmunity
C-Reactive Protein / immunology*
Humans
Mice
Plant Oils / poisoning*
Chemical
Reg. No./Substance:
0/Aniline Compounds; 0/Autoantibodies; 0/Plant Oils; 8002-13-9/rapeseed oil; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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