Document Detail

The toxic effect of Amiodarone on valve formation in the developing heart of zebrafish embryos.
MedLine Citation:
PMID:  22227723     Owner:  NLM     Status:  Publisher    
BACKGROUND: Amiodarone is a class D drug given to treat arrhythmia, including pregnant women, but its effects on the developing heart have not been studied. Although some studies have suggested that this drug is safe for fetuses, they have been conducted on mothers with fetuses at or beyond six months of gestational age. RESULTS: The occurrence of valve defect was positively proportional to Amiodarone concentrations over 9μM, but not lower than 6μM. Ectopic overexpression of versican was observed at the atrioventricular canal of the Amiodarone-treated embryos at 15μM (EC(50)). VE-cadherin (cdh5), normally downregulated at the endocardial cushion, was also ectopically overexpressed in the Amiodarone-treated embryos. Knockdown of either versican or cdh5 in the Amiodarone-treated embryos could rescue the valve defect caused by Amiodarone. CONCLUSIONS: By inducing versican ectopical overexpression, leading, in turn, to cdh5 ectopical overexpression, Amiodarone treatment causes failure of cardiac valve formation in zebrafish embryos.
Ying-Hsin Chen; Ren-Jun Hsu; Ta-Yuan Chen; Yu-Kai Huang; Hung-Chieh Lee; Sheng-Chuan Hu; Horng-Jyh Harn; Jing-Ren Jeng; Chi-Kuang Sun; Shinn-Zong Lin; Huai-Jen Tsai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-29
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  -     ISSN:  1873-1708     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Institute of Medical Sciences, Buddhist Tzu Chi University, Taiwan; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
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