| toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration. | |
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MedLine Citation:
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PMID: 17409068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The primitive embryonic gonad in Drosophila melanogaster is composed of germ cells and somatic gonadal precursor cells (SGPs). The assembly of a functional gonad involves a complex series of germ-cell migration events, which are thought to be guided by attractive and repulsive cues. Here, we demonstrate a novel role for toutvelu (ttv), a regulator of heparan sulfate proteoglycan biosynthesis during this process. Germline clonal analysis suggests that maternal deposition of ttv is required for proper germ-cell migration. Conversely, ectopic expression of ttv in early embryos results in severe germ-cell migration defects and inappropriate spreading of Hh protein. Moreover, overexpression of ttv in only the receiving cells, rather than in the sending cells, leads to phenotypic consequences. Finally, supporting the claim that the signaling molecule Hedgehog (Hh) may function as a chemoattractant to guide germ cells, errant germ cells are found localized near pockets containing high concentrations of Hh protein. |
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Authors:
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Girish Deshpande; Nilay Sethi; Paul Schedl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-03 |
Journal Detail:
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Title: Genetics Volume: 176 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2007-10-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
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Languages: eng Pagination: 905-12 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement Cues Drosophila Proteins / genetics, physiology* Drosophila melanogaster / cytology, embryology, genetics, physiology* Female Gene Expression Regulation Germ Cells / cytology, physiology* Heparan Sulfate Proteoglycans / biosynthesis* Immunohistochemistry Membrane Proteins / genetics, physiology* Oviposition |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Heparan Sulfate Proteoglycans; 0/Membrane Proteins; 0/tout-velu protein, Drosophila |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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