| The topography of nerve cell loss from the locus caeruleus in elderly persons. | |
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MedLine Citation:
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PMID: 2755557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A topographical analysis of nerve cell loss from the locus caeruleus in "mentally normal" old people shows cell loss to be uniformly diffuse throughout the whole nucleus with no preferential involvement of any one particular area. Such findings contrast with those of ours on Alzheimer's disease and suggest differing mechanisms underlying the cell loss of old age and Alzheimer's disease. Cell loss in Alzheimer's disease is thought to relate to primary pathogenetic events in terminal fields of cerebral cortex. In "normal" old age, cell loss may be determined by changes occurring at perikaryal level possibly in respect of the cytotoxic effects of noradrenaline degradation and neuromelanin accumulation. |
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Authors:
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B Marcyniuk; D M Mann; P O Yates |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurobiology of aging Volume: 10 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 1989 Jan-Feb |
Date Detail:
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Created Date: 1989-08-31 Completed Date: 1989-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Manchester, Great Britain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aging / pathology* Cell Count Cell Survival Female Humans Locus Coeruleus / pathology* Male Middle Aged Neurons / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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