Document Detail


The topographical distribution of tissue injury in benign MS: a 3T multiparametric MRI study.
MedLine Citation:
PMID:  18155611     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the global and regional distribution of white matter (WM) and gray matter (GM) damage and T2-visible lesion between patients with benign (B) and relapsing remitting (RR) multiple sclerosis (MS). BMS and RRMS patients did not differ in terms of global volumes and diffusion tensor (DT) MRI metrics of the WM and GM. Compared to controls, BMS and RRMS patients had bilateral thalamic loss. Compared to controls, BMS and RRMS patients had lower WM fractional anisotropy (FA) in the corpus callosum (CC) and in several regions of temporal and occipital lobes. BMS also had a decreased WM FA in the parietal lobes. RRMS patients had also lower WM FA in several regions of the frontal lobes. Compared to BMS, RRMS patients had decreased WM FA in the frontal lobes, while the opposite comparison showed lower WM FA in the CC, the temporal lobes and the cuneus in BMS. Contrasted to controls, both MS groups showed several regions of increased MD in WM and GM, but no difference was found between MS sub-groups. T2-visible lesions were mainly located in the posterior regions of the brain in BMS patients, while they involved also regions in the frontal lobes, in RRMS patients. BMS and RRMS patients differ in terms of the topographical distribution of WM damage rather than in the overall extent of brain structural changes. The less prominent involvement of the frontal lobe WM and of the NAWM in general in BMS might be associated to their favorable clinical status.
Authors:
Antonia Ceccarelli; Maria A Rocca; Elisabetta Pagani; Angelo Ghezzi; Ruggero Capra; Andrea Falini; Giuseppe Scotti; Giancarlo Comi; Massimo Filippi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-13
Journal Detail:
Title:  NeuroImage     Volume:  39     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1499-509     Citation Subset:  IM    
Affiliation:
Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anisotropy
Atrophy
Brain / pathology*
Brain Mapping
Diffusion Magnetic Resonance Imaging
Female
Humans
Image Processing, Computer-Assisted
Male
Multiple Sclerosis / pathology*
Multiple Sclerosis, Relapsing-Remitting
Nerve Fibers / pathology
Nonlinear Dynamics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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