Document Detail

Is topical nitric oxide and cryotherapy more effective than cryotherapy in the treatment of old world cutaneous leishmaniasis?
MedLine Citation:
PMID:  20964568     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Current systemic treatments for cutaneous leishmaniasis are limited by their toxicity, high cost, side effects and the emergence of drug resistance. New approaches, including topical therapies, are urgently needed. Nitric oxide (NO) produced by human and canine macrophages has long been demonstrated to be involved in the intracellular killing of Leishmania.
OBJECTIVE: This study was designed to determine the clinical responses (healing, or non-healing) and effectiveness of NO plus cryotherapy for the treatment of old world cutaneous leishmaniasis (CL).
METHODS: A double-blind, randomized, placebo-controlled clinical trial was performed for the evaluation of therapy with topical nitric oxide 3% and cryotherapy in 63 Iranian patients with CL in the south of Iran.
RESULTS: Thirty of 36 participants (83.3%) had complete improvement in the treatment group as did 20 of 27 (74.1%) from the control group (p = 0.627). Erythema, a burning sensation and irritation occurred in seven participants from the treatment group and one patient from the placebo group (p = 0.063).
CONCLUSION: This study could not show any more effectiveness from combining a 12-week course of treatment with 3% nitric oxide cream and a once-weekly treatment with cryotherapy in comparison with cryotherapy and placebo in patients with CL.
Farideh Jowkar; Farideh Dehghani; Akram Jamshidzadeh
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-10-22
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  23     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-08-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
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MeSH Terms
Antiparasitic Agents / administration & dosage,  therapeutic use*
Combined Modality Therapy
Double-Blind Method
Leishmania major
Leishmania tropica
Leishmaniasis, Cutaneous / parasitology,  therapy*
Middle Aged
Nitric Oxide / administration & dosage,  therapeutic use*
Young Adult
Reg. No./Substance:
0/Antiparasitic Agents; 31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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