Document Detail

The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
MedLine Citation:
PMID:  2880988     Owner:  NLM     Status:  MEDLINE    
A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.
D J Schrier; S Moniot; M I Gluckman; R B Gilbertsen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  39     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-20     Completed Date:  1987-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Administration, Topical
Anthranilic Acids / administration & dosage*
Anti-Inflammatory Agents*
Edema / chemically induced,  drug therapy
Indomethacin / administration & dosage
Meclofenamic Acid / administration & dosage*
Mice, Inbred C57BL
Reg. No./Substance:
0/Anthranilic Acids; 0/Anti-Inflammatory Agents; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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