Document Detail


The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
MedLine Citation:
PMID:  2880988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A topical preparation of meclofenamic acid (Meclomen) was tested for anti-inflammatory activity in a murine model of carrageenan footpad oedema. The preparation significantly inhibited swelling when applied to the carrageenan-injected paw. Maximum inhibition was observed 4-5 h after carrageenan injection. The topical effects could not be attributed to systemic absorption because the preparation was more inhibitory when applied topically to the carrageenan-injected paw than to a distant site or orally.
Authors:
D J Schrier; S Moniot; M I Gluckman; R B Gilbertsen
Related Documents :
6287818 - Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic a...
17354468 - Azelaic acid gel 15%: clinical versatility in the treatment of rosacea.
10986668 - Studies on the extracellular tannase from newly isolated bacillus licheniformis kbr 6.
9821668 - Anti-inflammatory activity in rats and mice of phenolic acids isolated from scrophulari...
14717368 - Combined effect of electron-beam (beta) irradiation and organic acids on shelf life of ...
22455758 - Usual folic acid intakes: a modelling exercise assessing changes in the amount of folic...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  39     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-20     Completed Date:  1987-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Topical
Animals
Anthranilic Acids / administration & dosage*
Anti-Inflammatory Agents*
Carrageenan
Edema / chemically induced,  drug therapy
Female
Indomethacin / administration & dosage
Meclofenamic Acid / administration & dosage*
Mice
Mice, Inbred C57BL
Chemical
Reg. No./Substance:
0/Anthranilic Acids; 0/Anti-Inflammatory Agents; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipid vehicles for intestinal lymphatic drug absorption.
Next Document:  Effects of microiontophoretic pentobarbitone on conditioned inhibitions mediated by GABA-A receptors...